In one story, the focus is on Dr. Tracy Grikscheit, a CIRM-funded pediatric surgeon at Children’s Hospital Los Angeles, and the work she does in helping treat children who are born with a disorder that causes their intestinal tissue to die. Much of her work is done surgically, trying to conserve as much of the intestine as possible so that the child can lead as normal a life as possible.
But surgery can only do so much so Dr. Grikscheit spends a lot of time in the lab, working with stem cells to try and find a way to make replacement intestines for infants. As she points out in the story:
Not much new intestine would be required. “You only need to engineer an organ up to the point where you fix the missing function,” Dr. Grikscheit said. Even a couple of inches might be enough. “That will tip them back over into having enough absorptive function to get off of I.V. nutrition and live a full life.”This is clearly important work and we are helping her do it. Dr. Grikscheit is a recipient of a CIRM New Faculty Award. She got almost $2.4 million to help support her and fund the research she is doing. Grants like this are particularly important for researchers who are doing innovative work and who are at an early point in their career where finding funding can be difficult.
Dr. Grikscheit has already had some success in her work, and although she knows it may be many years before the techniques she is developing are ready to be tested in people she says in the New York Times article that she is optimistic she’ll get there:
“The really fascinating thing is how to put something together that came out wrong and make it as right as possible.”If you want to hear more about Grikscheit's work, listen to her explanation in this video we shot. She was at a tissue engineering workshop we hosted last year, which brought together some of the leading researchers who are combing stem cells and engineering to help generate new intestines, windpipes, bones and a range of other therapies.