In the scientific symposium session titled “A Chemical Approach to Regenerative Medicine,” Mark Mercola, Ph.D., professor and director of the Muscle Development and Regeneration Program at Sanford-Burnham, will present the results of a study performed to discover drug targets and RNA therapeutics for heart failure.For more about his work, here's a video we shot with Dr. Mercola:
The study shows how a high-throughput chemical and functional-genomics screening strategy using iPSC-derived cardiac myocytes—heart muscle cells—identified a number of molecules that modulate cell differentiation and contractility. By inhibiting one of these molecules with antisense RNA, the scientists were able to halt the progression of heart failure and restore cardiac functions in mouse models of heart failure.
“There is an urgent need for therapies that reverse the course of ventricular dysfunction in heart failure, the leading cause of morbidity and mortality in the United States. Using the Prebys Center’s ultra-high-throughput screening technology, our efforts to discover a drug that rescues heart-muscle activity have been productive,” said Mercola.